On 10 October 2018, the acquisition of the two companies SciCan (disinfection equipment and hygiene products) and MicroMega (endodontic instruments) is successfully completed. With the integration of the two dental specialists, COLTENE significantly increases group sales and employs around 1,400 people.

Diatech LLC, headquartered in Mount Pleasant, South Carolina, USA, will be acquired on March 24, 2017. COLTENE integrates the business unit into the newly founded Diatech INC, a subsidiary of Coltène/Whaledent INC.

The acquisition of KENDA AG, headquartered in Vaduz, Liechtenstein, by COLTENE Holding AG has been announced on 19 December 2017. KENDA was founded in 1977 and is an international specialist for dental silicone polishers.

On October 29, 2010, COLTENE Holding AG acquires the remaining 60% of the Brazilian company Vigodent SA Indùstria e Comércio, Bonsucesso/Rio de Janeiro.

On July 1, 2009, COLTENE Holding AG acquires a 40% stake in the Brazilian company Vigodent SA Indústria e Comércio, Bonsucesso/Rio de Janeiro.

On February 27, 2008, Medisize Holding AG sells its complete medical business to Medifiq Healthcare OY (Finland) and changes its name to COLTENE Holding AG. COLTENE is now exclusively focused on the dental market.

COLTENE acquires CEI Cutting Edge Instruments, Inc., USA (Bridgewater Corners, Vermont).
The former Health Care Division of the Swiss Gurit-Heberlein Group goes public on June 23, 2006 on the SIX Swiss Exchange. The independent company is listed as Medisize Holding AG. 

Until 2006, reporting of dental market activities (now COLTENE) were part of the Healtchcare Division of Gurit Holding AG (see www.gurit.com).